Third-Generation GLP-1
Triple GLP-1/GIP/Glucagon Agonist
Best For
Advanced metabolic protocols, visceral fat reduction, body composition optimization
Triple
Three receptor pathways studied for metabolic effects
3
Receptor pathways activated simultaneously
Appetite
Appetite signaling examined in study participants
How It Works
This third-generation GLP-1 is the first triple agonist — activating GLP-1, GIP, and glucagon receptors simultaneously. The glucagon receptor activation is the differentiator: it increases daily energy expenditure by stimulating hepatic fat oxidation and thermogenesis. This three-pronged approach addresses appetite, insulin sensitivity, and metabolic rate in a single molecule.
Key Research Areas
Triple Mechanism
Broadest receptor pathway activation — 3 mechanisms at once
Energy Expenditure
Enhances daily caloric burn via glucagon activation
Visceral Fat
Preferentially targets deep abdominal adipose tissue
Lean Mass
Preserves muscle during aggressive fat reduction
Research Highlights
- Broadest receptor pathway activation — 3 mechanisms at once
- Enhances daily energy expenditure and lean mass preservation
Featured Research
Formulation Notes
Common concentrations referenced in published clinical studies:
[RT20]20mg[RT30]30mgCategory
GLP-1, GIP, and glucagon receptor agonists represent the most significant advance in metabolic medicine. These peptides ...
Explore Lean Body category →Educational Content. This compound profile is for informational purposes only. Not intended as medical advice, diagnosis, or treatment.
Related Compounds
Second-Generation GLP-1
Dual GIP/GLP-1 Agonist
- Superior to single-agent therapies in every trial
- Activates two incretin pathways for broader metabolic impact
Reference Codes
[TR20]20mg[TR40]40mgFirst-Generation GLP-1
GLP-1 Receptor Agonist
- Most-studied GLP-1 agonist with over 10,000 participants across STEP trials
- Demonstrated cardiovascular benefit independent of weight loss
Reference Codes
[SM5]5mg[SM10]10mg[SM15]15mg[SM20]20mg[SM30]30mgAmylin + GLP-1 Combination
Amylin + GLP-1 Dual Agonist
- First combination to pair amylin and GLP-1 agonism in a single protocol
- Additive weight loss beyond what either pathway achieves alone
Reference Codes
[CS10]10mg (Amylin 5mg + GLP-1 5mg)Evidence reviewed: March 2026