Semax
Nootropic Neuroprotective Peptide
Best For
Cognitive optimization, neuroprotection protocols, clients seeking sharper mental clarity
BDNF
Primary neurotrophic factor enhanced
NGF
Secondary growth factor upregulated
ACTH
Derived from ACTH(4-10) fragment
How It Works
Semax is a synthetic analogue of the ACTH(4-10) fragment, stabilized with a Pro-Gly-Pro C-terminal extension to resist enzymatic degradation. It upregulates both brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in cortical and hippocampal regions, promoting neuronal survival, dendritic branching, and synaptic density. Semax also modulates serotonergic and dopaminergic activity, contributing to sustained attention and neuroprotection against oxidative and ischemic insults.
Key Research Areas
Cognitive Enhancement
BDNF and NGF upregulation sharpen focus, memory, and processing speed
Neuroprotection
Protects neurons against oxidative stress and ischemic damage
Attention & Focus
Modulates dopamine and serotonin for sustained cognitive engagement
Neural Repair
Promotes dendritic branching and synaptic density over time
Research Highlights
- Dual BDNF and NGF upregulation for broad neurotrophic support
- ACTH-derived peptide with nootropic and neuroprotective properties
Featured Research
Formulation Notes
Common concentrations referenced in published clinical studies:
[XA5]5mg[XA11]10mgCategory
Cognitive enhancement and neuroprotection through targeted peptide signaling. These compounds modulate BDNF, NGF, and GA...
Explore Mind category →Educational Content. This compound profile is for informational purposes only. Not intended as medical advice, diagnosis, or treatment.
Evidence reviewed: March 2026