The Sol Report
vitality

HCG (Human Chorionic Gonadotropin)

LH-Mimetic Glycoprotein Hormone

Best For

Hormonal optimization support, fertility preservation, testicular function maintenance

LH

Receptor pathway mimicked

StAR

Steroidogenic pathway activated

HPG

Axis supported during optimization

How It Works

Human chorionic gonadotropin is a heterodimeric glycoprotein that shares structural homology with luteinizing hormone, binding directly to LH/CG receptors on Leydig cells in the testes. This activation stimulates the steroidogenic acute regulatory (StAR) pathway, driving intratesticular testosterone synthesis and maintaining spermatogenesis. HCG preserves testicular volume and function during protocols that would otherwise suppress the hypothalamic-pituitary-gonadal axis, making it a critical adjunct in hormonal optimization.

Key Research Areas

Testosterone Support

Stimulates intratesticular testosterone production via LH receptor activation

Testicular Function

Preserves Leydig cell activity and testicular volume

Spermatogenesis

Maintains sperm production during hormonal optimization protocols

HPG Axis Support

Prevents gonadal suppression when used as a protocol adjunct

Research Highlights

  • LH-mimetic action preserves testicular function during hormonal protocols
  • Maintains spermatogenesis and intratesticular testosterone production

Featured Research

HCG: Fertility Preservation, Testosterone Support, and What the Evidence Shows

Read Sol's deep dive →

Formulation Notes

Common concentrations referenced in published clinical studies:

[G5K]5000iu[G10K]10000iu

Category

Vitality

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Educational Content. This compound profile is for informational purposes only. Not intended as medical advice, diagnosis, or treatment.

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Evidence reviewed: March 2026