Melanotan II
Non-Selective Melanocortin Agonist
Best For
Clients interested in melanocortin pathway research, pigmentation and libido protocols
MC1R
Melanogenesis receptor target
MC3/4R
Libido-related receptor activation
Broad
Non-selective receptor binding profile
How It Works
Melanotan II is a cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone that activates multiple melanocortin receptor subtypes. MC1R activation stimulates melanogenesis in dermal melanocytes, increasing eumelanin production independent of UV exposure. Simultaneous MC3R and MC4R activation in hypothalamic nuclei influences libido and sexual arousal pathways. Research notes broad receptor affinity as a consideration — the non-selective binding profile means effects extend beyond any single target system.
Key Research Areas
Melanogenesis
MC1R activation increases eumelanin production for photoprotective pigmentation
Libido Support
MC3R/MC4R signaling enhances sexual arousal and desire pathways
Photoprotection
Elevated melanin provides a degree of endogenous UV defense
Research Interest
Broad melanocortin activity makes it one of the most-studied peptides in this class
Research Highlights
- Stimulates melanin production independent of UV exposure via MC1R
- Non-selective melanocortin agonist with multi-receptor activity
Featured Research
Formulation Notes
Common concentrations referenced in published clinical studies:
[ML10]10mgCategory
Sexual health, hormonal optimization, and reproductive function represent some of the most personal — and most searched ...
Explore Vitality category →Educational Content. This compound profile is for informational purposes only. Not intended as medical advice, diagnosis, or treatment.
Related Compounds
PT-141 (Bremelanotide)
Melanocortin Receptor Agonist
- Only FDA-approved peptide that addresses sexual desire through central nervous system pathways
- Effective in populations that do not respond to PDE5 inhibitors
Reference Codes
[P41]10mgHCG (Human Chorionic Gonadotropin)
LH-Mimetic Glycoprotein Hormone
- LH-mimetic action preserves testicular function during hormonal protocols
- Maintains spermatogenesis and intratesticular testosterone production
Reference Codes
[G5K]5000iu[G10K]10000iuEvidence reviewed: March 2026