SS-31 (Elamipretide)
Mitochondrial Membrane Protector
Best For
Mitochondrial support protocols, cellular energy optimization, age-related energy decline
IMM
Targets inner mitochondrial membrane directly
ROS
Reduces oxidative stress at the source
Phase 3
Clinical trials in Barth syndrome and heart failure
How It Works
SS-31 is a mitochondrial-targeted peptide that binds cardiolipin in the inner mitochondrial membrane, stabilizing electron transport chain complexes and reducing mitochondrial reactive oxygen species (ROS) production at the source. By preserving membrane architecture, it maintains efficient oxidative phosphorylation and ATP output. Clinical trials in Barth syndrome and heart failure demonstrate measurable functional improvement.
Key Research Areas
Cardiolipin Stabilization
Protects the lipid scaffold essential for electron transport chain integrity
ROS Reduction
Lowers mitochondrial oxidative stress at the point of generation
ATP Efficiency
Supports optimal energy production by maintaining membrane structure
Cellular Resilience
Clinical evidence of functional improvement in mitochondrial dysfunction
Research Highlights
- One of the only peptides that targets mitochondrial membranes directly
- Reduces ROS at the source rather than scavenging downstream free radicals
Featured Research
Formulation Notes
Common concentrations referenced in published clinical studies:
[2S10]10mg[2S50]50mgCategory
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Explore Recharge category →Educational Content. This compound profile is for informational purposes only. Not intended as medical advice, diagnosis, or treatment.
Related Compounds
NAD+
Longevity Coenzyme
- Powers cellular energy, sirtuin activation, DNA repair
- ~50% decline by age 50 — restoration supports all function
Reference Codes
[NJ500]500mgMOTS-c
Mitochondrial-Derived Signaling Peptide
- First mitochondrial-derived peptide shown to translocate to the nucleus and regulate gene expression
- Identified by the Lee Lab at USC — a leading center for mitochondrial peptide research
Reference Codes
[MS10]10mg[MS40]40mgEpitalon (Epithalon)
Telomerase Activator Tetrapeptide
- Backed by over two decades of research from the St. Petersburg Institute of Bioregulation
- One of the few compounds shown to activate telomerase in human somatic cells
Reference Codes
[ET10]10mg[ET50]50mgEvidence reviewed: March 2026